{"id":1034,"date":"2012-09-01T00:00:00","date_gmt":"2012-09-01T00:00:00","guid":{"rendered":"http:\/\/sltr.local\/?p=1034"},"modified":"2023-09-15T10:39:49","modified_gmt":"2023-09-15T10:39:49","slug":"genetic-and-environmental-etiology-of-nicotine-use-in-sri-lankan-male-twins","status":"publish","type":"post","link":"https:\/\/sltr.ird.lk\/si\/publication\/genetic-and-environmental-etiology-of-nicotine-use-in-sri-lankan-male-twins\/","title":{"rendered":"Genetic and Environmental Etiology of Nicotine Use in Sri Lankan Male Twins"},"content":{"rendered":"\n<div id=\"publication-container\" class=\"wp-block-uagb-container uagb-block-e833c822 alignfull uagb-is-root-container\"><div class=\"uagb-container-inner-blocks-wrap\">\n<div class=\"wp-block-uagb-container uagb-block-8024b029\">\n<p>Helena M. S. Zavos, Yulia Kovas, Harriet A. Ball, David Ball, Sisira H. Siribaddana, Nick Glozier, Athula Sumathipala, Peter McGuffin, Matthew Hotopf &amp; Fr\u00fchling V. Rijsdijk<\/p>\n\n\n<div class=\"publish-date wp-block-post-date\"><time datetime=\"2012-09-01T00:00:00+00:00\">September 2012<\/time><\/div>\n\n<div class=\"taxonomy-category wp-block-post-terms\"><a href=\"https:\/\/sltr.ird.lk\/si\/category\/publication\/papers\/\" rel=\"tag\">Papers<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/sltr.ird.lk\/si\/category\/publication\/\" rel=\"tag\">Publication<\/a><\/div>\n\n\n<p>Behavior Genetics, Volume 42, Issue 5, Pages 798 \u2013 807<\/p>\n\n\n\n<p>doi:<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1007\/s10519-012-9544-z\" target=\"_blank\">https:\/\/doi.org\/10.1007\/s10519-012-9544-z<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-33811260\">\n<h2 class=\"wp-block-heading has-text-align-left\">Abstract<\/h2>\n\n\n\n<p>Little is known about the prevalence and etiology of tobacco use in Asian populations. This study aims to test whether the finding of substantial heritability for tobacco-related phenotypes in Western populations is generalizable to developing countries. The twin method was used to estimate the relative contribution of genetic and environmental influences on nicotine-related phenotypes. Participants were selected from the population based Sri Lankan Twin Registry. The Composite International Diagnostic Interview was administered to 1,804 male individuals to assess five phenotypes: nicotine use; desire and unsuccessful attempts to quit smoking; subjective feeling of being tobacco dependent; and two DSM-IV diagnoses; nicotine dependence and nicotine withdrawal. <\/p>\n\n\n\n<p>Almost one-third of the male twins were life-time smokers. The genetic results were consistent with the previously reported findings from Western and Chinese populations, in that the nicotine use traits were significantly heritable, with environmental influences being of the non-shared nature. The results derived from the Causal Contingent Common pathway model (CCC) supported previous findings that show that liabilities to regular smoking and subsequent problem smoking have both shared and specific genetic influences.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-8b71c1c5\">\n<div class=\"wp-block-uagb-container uagb-block-68630121\">\n<div class=\"wp-block-uagb-container uagb-block-5e518491\">\n<p>Website:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-87ee0c4a\">\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10519-012-9544-z\">Genetic and Environmental Etiology of Nicotine Use in Sri Lankan Male Twins | SpringerLink<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-0fcdaf73\">\n<div class=\"wp-block-uagb-container uagb-block-aa1e510a\">\n<p>PDF:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-8d389701\">\n<p><a href=\"https:\/\/www.ird.lk\/wp-content\/uploads\/2015\/03\/Genetic-and-Environmental-Etiology-of-Nicotine-Use-in-Sri-Lankan-Male-Twins.pdf\">https:\/\/www.ird.lk\/wp-content\/uploads\/2015\/03\/Genetic-and-Environmental-Etiology-of-Nicotine-Use-in-Sri-Lankan-Male-Twins.pdf<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Little is known about the prevalence and etiology of tobacco use in Asian populations. This study aims to test whether the finding of substantial heritability for tobacco-related phenotypes in Western populations is generalizable to developing countries.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[10,4],"tags":[],"class_list":["post-1034","post","type-post","status-publish","format-standard","hentry","category-papers","category-publication"],"translation":{"provider":"WPGlobus","version":"3.0.0","language":"si","enabled_languages":["en","si","ta"],"languages":{"en":{"title":true,"content":true,"excerpt":true},"si":{"title":false,"content":false,"excerpt":false},"ta":{"title":false,"content":false,"excerpt":false}}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"admin","author_link":"https:\/\/sltr.ird.lk\/si\/author\/admin\/"},"uagb_comment_info":0,"uagb_excerpt":"Little is known about the prevalence and etiology of tobacco use in Asian populations. This study aims to test whether the finding of substantial heritability for tobacco-related phenotypes in Western populations is generalizable to developing countries.","_links":{"self":[{"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/posts\/1034","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/comments?post=1034"}],"version-history":[{"count":4,"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/posts\/1034\/revisions"}],"predecessor-version":[{"id":1576,"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/posts\/1034\/revisions\/1576"}],"wp:attachment":[{"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/media?parent=1034"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/categories?post=1034"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sltr.ird.lk\/si\/wp-json\/wp\/v2\/tags?post=1034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}