{"id":1024,"date":"2009-12-01T00:00:00","date_gmt":"2009-12-01T00:00:00","guid":{"rendered":"http:\/\/sltr.local\/?p=1024"},"modified":"2023-09-17T16:34:22","modified_gmt":"2023-09-17T16:34:22","slug":"genetic-and-environmental-contributions-to-depression-in-sri-lanka","status":"publish","type":"post","link":"https:\/\/sltr.ird.lk\/ta\/publication\/genetic-and-environmental-contributions-to-depression-in-sri-lanka\/","title":{"rendered":"Genetic and environmental contributions to depression in Sri Lanka"},"content":{"rendered":"\n<div id=\"publication-container\" class=\"wp-block-uagb-container uagb-block-fc093452 alignfull uagb-is-root-container\"><div class=\"uagb-container-inner-blocks-wrap\">\n<div class=\"wp-block-uagb-container uagb-block-8024b029\">\n<p>Harriet A. Ball, Athula Sumathipala, Sisira H. Siribaddana, Yulia Kovas, Nick Glozier, Peter McGuffin &amp; Matthew Hotopf<\/p>\n\n\n<div class=\"publish-date wp-block-post-date\"><time datetime=\"2009-12-01T00:00:00+00:00\">December 2009<\/time><\/div>\n\n<div class=\"taxonomy-category wp-block-post-terms\"><a href=\"https:\/\/sltr.ird.lk\/ta\/category\/publication\/papers\/\" rel=\"tag\">Papers<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/sltr.ird.lk\/ta\/category\/publication\/\" rel=\"tag\">Publication<\/a><\/div>\n\n\n<p>British Journal of Psychiatry, Volume 195, Issue 6, Pages 504 \u2013 509<\/p>\n\n\n\n<p>doi:<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1192\/bjp.bp.109.063529\" target=\"_blank\">10.1192\/bjp.bp.109.063529<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-33811260\">\n<h2 class=\"wp-block-heading has-text-align-left\">Abstract<\/h2>\n\n\n\n<p><strong>Background<\/strong><br>Susceptibility to depression results from genetic and non-familially shared environmental influences in high-income, Western countries. Environments may play a different role for populations in different contexts.<\/p>\n\n\n\n<p><strong>Aims<\/strong><br>To examine heritability of depression in the first large, population-based twin study in a low-income country.<\/p>\n\n\n\n<p><strong>Method<\/strong><br>Lifetime depression and a broader measure of depression susceptibility (D-probe) were assessed in 3908 adult twins in Sri Lanka (the CoTASS study).<\/p>\n\n\n\n<p><strong>Results<\/strong><br>There were gender differences for the broad definition (D-probe), with a higher genetic contribution in females (61%) than males (4%). Results were similar for depression, but the prevalence was too low to estimate heritability for males.<\/p>\n\n\n\n<p><strong>Conclusions<\/strong><br>Genetic influences on depression in women appear to be at least as strong in this Sri Lankan sample as in higher-income countries. Conclusions are less clear for men but suggest a larger role for environments rather than genes. The nature as well as the magnitude of environmental influences may also differ across populations.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-8b71c1c5\">\n<div class=\"wp-block-uagb-container uagb-block-68630121\">\n<div class=\"wp-block-uagb-container uagb-block-5e518491\">\n<p>Website:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-87ee0c4a\">\n<p><a href=\"https:\/\/www.cambridge.org\/core\/journals\/the-british-journal-of-psychiatry\/article\/genetic-and-environmental-contributions-to-depression-in-sri-lanka\/E9EF9C81BEE68AD0C871338B69F563F0\">Genetic and environmental contributions to depression in Sri Lanka | The British Journal of Psychiatry | Cambridge Core<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-0fcdaf73\">\n<div class=\"wp-block-uagb-container uagb-block-aa1e510a\">\n<p>PDF:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-8d389701\">\n<p><a href=\"https:\/\/www.ird.lk\/wp-content\/uploads\/2015\/03\/Genetic-and-environmental-contributions-to-depression-in-Sri-Lanka.pdf\">https:\/\/www.ird.lk\/wp-content\/uploads\/2015\/03\/Genetic-and-environmental-contributions-to-depression-in-Sri-Lanka.pdf<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Susceptibility to depression results from genetic and non-familially shared environmental influences in high-income, Western countries. Environments may play a different role for populations in different contexts.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[10,4],"tags":[],"class_list":["post-1024","post","type-post","status-publish","format-standard","hentry","category-papers","category-publication"],"translation":{"provider":"WPGlobus","version":"3.0.0","language":"ta","enabled_languages":["en","si","ta"],"languages":{"en":{"title":true,"content":true,"excerpt":true},"si":{"title":false,"content":false,"excerpt":false},"ta":{"title":false,"content":false,"excerpt":false}}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"admin","author_link":"https:\/\/sltr.ird.lk\/ta\/author\/admin\/"},"uagb_comment_info":0,"uagb_excerpt":"Susceptibility to depression results from genetic and non-familially shared environmental influences in high-income, Western countries. Environments may play a different role for populations in different contexts.","_links":{"self":[{"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/posts\/1024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/comments?post=1024"}],"version-history":[{"count":4,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/posts\/1024\/revisions"}],"predecessor-version":[{"id":1588,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/posts\/1024\/revisions\/1588"}],"wp:attachment":[{"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/media?parent=1024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/categories?post=1024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/tags?post=1024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}