{"id":2078,"date":"2020-02-02T05:33:00","date_gmt":"2020-02-02T05:33:00","guid":{"rendered":"http:\/\/sltr.local\/?p=2078"},"modified":"2023-10-02T05:38:00","modified_gmt":"2023-10-02T05:38:00","slug":"genetic-overlap-between-type-2-diabetes-and-depression-in-a-sri-lankan-population-twin-sample","status":"publish","type":"post","link":"https:\/\/sltr.ird.lk\/ta\/publication\/genetic-overlap-between-type-2-diabetes-and-depression-in-a-sri-lankan-population-twin-sample\/","title":{"rendered":"Genetic Overlap Between Type 2 Diabetes and Depression in a Sri Lankan Population Twin Sample"},"content":{"rendered":"\n<div id=\"publication-container\" class=\"wp-block-uagb-container uagb-block-85967e23 alignfull uagb-is-root-container\"><div class=\"uagb-container-inner-blocks-wrap\">\n<div class=\"wp-block-uagb-container uagb-block-8024b029\">\n<p>Kan, Carol MRCPsych, PhD; Jayaweera, Kaushalya MD; Adikari, Anushka MD; Siribaddana, Sisira FRCP; Zavos, Helena M.S. PhD; Harber-Aschan, Lisa PhD; Sumathipala, Athula PhD; Hotopf, Matthew PhD, FRCPsych; Ismail, Khalida MRCPsych, PhD; Rijsdijk, Fr\u00fchling PhD<\/p>\n\n\n<div class=\"publish-date wp-block-post-date\"><time datetime=\"2020-02-02T05:33:00+00:00\">February 2020<\/time><\/div>\n\n<div class=\"taxonomy-category wp-block-post-terms\"><a href=\"https:\/\/sltr.ird.lk\/ta\/category\/publication\/papers\/\" rel=\"tag\">Papers<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/sltr.ird.lk\/ta\/category\/publication\/\" rel=\"tag\">Publication<\/a><\/div>\n\n\n<p>Psychosomatic Medicine \u00a0Volume 82\u00a0&#8211;\u00a0Issue 2<\/p>\n\n\n\n<p>doi: 10.1097\/PSY.0000000000000771<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-33811260\">\n<h2 class=\"wp-block-heading has-text-align-left\">Abstract<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Objective&nbsp;<\/h3>\n\n\n\n<p>Results from twin studies examining the genetic overlap between type 2 diabetes and depression are currently inconclusive. This question has not been addressed in non-Western populations. We aimed to examine whether there are common genetic factors between type 2 diabetes and depression in a Sri Lankan population using genetic model-fitting analysis.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Method&nbsp;<\/h3>\n\n\n\n<p>The Colombo Twin and Singleton Study\u2013Phase 2 consists of 2019 singletons, and 842 monozygotic and 578 dizygotic twin pairs. The primary outcomes were self-reported type 2 diabetes diagnosis and Beck Depression Inventory scores. Standard bivariate twin models were fitted to estimate the genetic and environmental (co)variance of type 2 diabetes and depression.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Results&nbsp;<\/h3>\n\n\n\n<p>In the best-fitting model, the phenotypic correlation between type 2 diabetes and depression was significant in female individuals only (<em>r<\/em>&nbsp;= 0.15 [0.08\u20130.21]). This association was primarily attributed to a significant genetic correlation between the traits (rA = 0.53 [0.19\u20130.98]).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Conclusions&nbsp;<\/h3>\n\n\n\n<p>In female individuals, but not male individuals, we found a significant genetic overlap between type 2 diabetes and depression in the context of a modest phenotypic correlation.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-8b71c1c5\">\n<div class=\"wp-block-uagb-container uagb-block-68630121\">\n<div class=\"wp-block-uagb-container uagb-block-5e518491\">\n<p>Website:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-87ee0c4a\">\n<p><a href=\"https:\/\/journals.lww.com\/psychosomaticmedicine\/fulltext\/2020\/02000\/genetic_overlap_between_type_2_diabetes_and.15.aspx\">Genetic Overlap Between Type 2 Diabetes and Depression in a&#8230; : Psychosomatic Medicine (lww.com)<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-0fcdaf73\">\n<div class=\"wp-block-uagb-container uagb-block-aa1e510a\">\n<p>PDF:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-container uagb-block-8d389701\">\n<p><a href=\"https:\/\/journals.lww.com\/psychosomaticmedicine\/_layouts\/15\/oaks.journals\/downloadpdf.aspx?trckng_src_pg=ArticleViewer&amp;an=00006842-202002000-00015\">Genetic Overlap Between Type 2 Diabetes and Depression in a Sri Lankan Population Twin Sample : Psychosomatic Medicine (lww.com)<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Kan, Carol MRCPsych, PhD; Jayaweera, Kaushalya MD; Adikari, Anushka MD; Siribaddana, Sisira FRCP; Zavos, Helena M.S. PhD; Harber-Aschan, Lisa PhD; Sumathipala, Athula PhD; Hotopf, Matthew PhD, FRCPsych; Ismail, Khalida MRCPsych, PhD; Rijsdijk, Fr\u00fchling PhD Psychosomatic Medicine \u00a0Volume 82\u00a0&#8211;\u00a0Issue 2 doi: 10.1097\/PSY.0000000000000771 Abstract Objective&nbsp; Results from twin studies examining the genetic overlap between type 2 diabetes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","footnotes":""},"categories":[10,4],"tags":[],"class_list":["post-2078","post","type-post","status-publish","format-standard","hentry","category-papers","category-publication"],"translation":{"provider":"WPGlobus","version":"3.0.0","language":"ta","enabled_languages":["en","si","ta"],"languages":{"en":{"title":true,"content":true,"excerpt":false},"si":{"title":false,"content":false,"excerpt":false},"ta":{"title":false,"content":false,"excerpt":false}}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"admin","author_link":"https:\/\/sltr.ird.lk\/ta\/author\/admin\/"},"uagb_comment_info":0,"uagb_excerpt":"Kan, Carol MRCPsych, PhD; Jayaweera, Kaushalya MD; Adikari, Anushka MD; Siribaddana, Sisira FRCP; Zavos, Helena M.S. PhD; Harber-Aschan, Lisa PhD; Sumathipala, Athula PhD; Hotopf, Matthew PhD, FRCPsych; Ismail, Khalida MRCPsych, PhD; Rijsdijk, Fr\u00fchling PhD Psychosomatic Medicine \u00a0Volume 82\u00a0&#8211;\u00a0Issue 2 doi: 10.1097\/PSY.0000000000000771 Abstract Objective&nbsp; Results from twin studies examining the genetic overlap between type 2 diabetes&hellip;","_links":{"self":[{"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/posts\/2078","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/comments?post=2078"}],"version-history":[{"count":1,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/posts\/2078\/revisions"}],"predecessor-version":[{"id":2079,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/posts\/2078\/revisions\/2079"}],"wp:attachment":[{"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/media?parent=2078"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/categories?post=2078"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sltr.ird.lk\/ta\/wp-json\/wp\/v2\/tags?post=2078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}